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About 50% of patients with melanoma have BRAF mutations and 1520% of NRAS mutations leading to the constitutive activation of the MAPK signaling pathway [2] and Chattopadhyay et al

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Moreover, concord grape juice was found safe and well-tolerated across 24-weeks

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However, the data supporting these recommendations are still preliminary, necessitating further large-scale clinical studies to establish true efficacy and, later, standardized protocols

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