This is likely due to greater weight loss seen in this trial, approximately 21% with 15 mg dosing, far exceeding the 14% weight loss observed in GLP-1 RA trials [14, 16, 19, 20, 23]
Among other undesirable effects, it may increase anxiety, cause the hydrochloric acid produced in the stomach to rise to the esophagus in people with gastroesophageal reflux, or bring about more epileptic fits in those who suffer with the condition
What is the MOQ for Semaglutide API
In addition, of the nine trials included in the sensitivity analysis of healthy individuals, three trials implemented a energy-restricted diet or exercise program in their intervention program
A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.ly/Q02QBfSp0 Therefore #T_Alpha by @biohaven will magic Phase III data for Spinal Muscular Atrophy will have readout this year
10.1016/j.cmet.2014.05.001 60 WolterJ