Ubiquitin-like (UBL) and ubiquitin-associated (UBA) domains within BAG6 and RAD23 prevent refolding or aggregation of emerging ERAD substrates, facilitating proteasomal delivery
J Clin Invest (2015) 125:106980
Figure 2 shows the mechanism of asparagine degradation by deamidation
Studies commonly focus on tendon and ligament injury models, muscle damage, wound healing, and gut irritation or ulcer models
Surfactants, both ionic and non-ionic, such as sodium lauryl sulfate, sodium laurate, polyoxyethylene-20-cetyl ether, laureth-9, sodium dodecylsulfate, dioctyl sodium sulfosuccinate, polyoxyethylene-9-lauryl ether (PLE),Tween80, nonylphenoxypolyethylene (NP-POE), polysorbates and the like, function as penetration enhancers
Other additions to Category 1 include ruxolitinib phosphate, a JAK1and JAK2 inhibitor currently commercially available orally and topically for conditions such as myelofibrosis or atopic dermatitis respectively and dimercaprol,a chelating drug currently commercially-available as an injectable