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A thorough review and analysis of randomized controlled trials assessed the effect of folic acid supplementation on homocysteine levels in type 2 diabetics

10.1038/s41419-020-03122-4 103 SzetoH

Important safety considerations when using these supplements together include: Drug interactions : Berberine may potentially interact with numerous medications, including antidiabetic drugs (increasing hypoglycaemia risk), anticoagulants, and medications metabolised by CYP450 enzymes (such as ciclosporin and certain statins)