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In transgenic FVB/N mice overexpressing the human HER-2/neu (erbB-2) oncogene, Epithalon administration results in a significant reduction in HER-2/neu mRNA levels, with a reported 3.7-fold decrease relative to saline controls

However, the metabolic pathways in cancer cells are different

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(1972a) The mutagenic effects of organophosphorus pesticides on microorganisms

We can indirectly assume ozone therapy influenced synthesis and release of cytokines (18,19) in such a way that a change from Th2 to Th1 (IL-2, IFNg) cytokine pattern occurs, or ozone therapy acted as Th2 cytokine inhibitor

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