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Participants with hepatic impairment were recruited before those with normal hepatic function to help ensure similarity across groups in age and body weight

The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate dehydrogenase (G6PD)

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Sleep architecture continues to normalize

It is purely for acclimatization

Many patients notice initial sleep benefits including easier sleep onset, fewer nighttime awakenings, or feeling more rested upon waking within the first few nights of therapy due to immediate effects on sleep-regulating systems