In patients with T2DM who do not have atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, HF, or CKD and who need to minimize hypoglycemia and/or promote weight loss, GLP-1 RAs are generally recommended as a second or third-line option as add-on to metformin therapy
doi: 10.1007/s13300-023-01379-4
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Despite the elevated heart rate, cardiovascular outcome trials have shown net cardiovascular benefits, suggesting that the modest chronotropic effect is outweighed by other protective mechanisms
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