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In the Metformin in Gestational Diabetes (MiG) trial published in 2008, in which patients were randomized to insulin versus metformin, there was a signal that there was an increased risk for elevated BMI and childhood overweight later in life at age 7 to 9 years in one of the cohorts

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E7 protein of human papilloma virus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteasome pathway