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Regardless, this model provides critical insights into how niche signaling is coordinated with downstream intrinsic effectors to govern the existence of a stem cell pool and its size

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A 2021 systematic review of 16 randomized controlled trials and 6,276 participants (Markun and colleagues, Effects of Vitamin B12 Supplementation on Cognitive Function, Depressive Symptoms, and Fatigue, Nutrients, 2021) found that B12 supplementation does not reliably reduce fatigue in people who are not deficient