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Researchers exploring why not losing weight on semaglutide or similar challenges should consider that weight loss plateaus are common after six to nine months and may require dose adjustments or lifestyle modifications

In a placebo-controlled trial conducted on patients having pre-existing coronary artery disease with preserved left ventricular function, increase in GLP-1 levels caused by DPP-4 inhibition resulted in improvement of global and regional left ventricular function and amelioration of post-ischemic stunning [70]

The benefits and risks of this medication should be carefully weighed on an individual basis

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