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Disclaimer: MT1 (Melanotan 1 / afamelanotide) is a research compound not approved by the U.S

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Acknowledgements We thank our colleagues in the protein production and QC teams for generating and validating the reagents used in this study

Interestingly, despite the lack of consistent actions of metformin in terms of metabolic profiles, treatment with the insulin sensitizer caused a complete normalization of ovarian cyclicity, pointing to a discernible reproductive effect of metformin in some PCOS conditions, in line with clinical literature 68 , although conflictive results have been reported also 69