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Amphetamine enters presynaptic neurons by passive diffusion and through plasma membrane monoamine transporters, including the dopamine transporter (DAT) in dopaminergic neurons, the norepinephrine transporter (NET) in adrenergic neurons, and the serotonin transporter (SERT) in serotinergic neurons

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In fact, GSH depletion obtained by BSO, the irreversible inhibitor of GCL, is the most frequently used approach and it is associated with many chemotherapeutic agents [5357]

Instead, cancer cells typically acquire cystine from the extracellular environment primarily through the aforementioned cystine transporter, system xc, which is then converted to cysteine (37)

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