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Advise patients to discontinue XIGDUO XR immediately and to promptly notify their healthcare provider if unexplained hyperventilation, myalgia, malaise, unusual somnolence, dizziness, slow or irregular heartbeat, sensation of feeling cold (especially in the extremities), or other nonspecific symptoms occur

PMID 22254022

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Therefore, given the lack of a significant relationship between adjusted and unadjusted scores, there was empirical evidence to support an unadjusted measure and that providers and facilities should be able to provide clear, personalized instruction to all patients about their recovery from a procedure or surgery