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Sikiric, P., et al

There are no large clinical trials proving that NAD+ injections reduce wrinkles, improve firmness, or rejuvenate the skin

(Clin Transl Med, 2021) in 24 older adults (aged 61-80) found that supplementation with GlyNAC (glycine 100 mg/kg/day + NAC 100 mg/kg/day, approximately 7 g each for a 70 kg person) for 16 weeks corrected glutathione deficiency and improved multiple hallmarks of aging including oxidative stress, mitochondrial dysfunction, inflammation, insulin resistance, endothelial dysfunction, body composition, exercise capacity, and cognition [10]

Great for health, but rough on industries that live off those habits

This is due to multiple factors including aging, estrogen decline, decrease in total 24-hour energy expenditure by 9 percent and spontaneous physical activity energy expenditure by 30 percent

What's particularly encouraging is the shift in mindset this represents: moving from 'treat with caution' to 'make it easier to prescribe'