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Furthermore, metformin regulates fatty acid (FA) synthesis through the AMPK/SREBP-1 pathway, thereby reducing the likelihood of malignant transformation in cancer cells (Zhou et al., 2024

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For example, the sensitization of TRPA1 with a low dose exposure to acrolein causes sensitization of TRPV1 against capsaicin.[ref] Studies in workplaces that have high VOC levels show that TRPA1 activation is the molecular initial event (MIE) leading to sensory irritation.[ref] A 2022 study investigated the sensitivity to capsaicin, a TRPV1 receptor activator, in people with MCS compared to a control group

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