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The 2022 List was approved by WADAs Executive Committee (ExCo) during its meeting on 14 September 2021 and was first published on 30 September 2021

Unlike oral supplements that require intrinsic factor for absorption in the gastrointestinal tract, vitamin B12 injections deliver the vitamin directly into bloodstream

In the case of pronounced absorption disorders, for example as a result of gastritis or after removal of the small intestine, in Crohn's disease, diverticulosis and the so-called blind-loop syndrome, there is a gradual decrease in the vitamin B12 store in the liver, which can turn into a manifest vitamin B12 deficiency

Too Much B-6 from Nuts June 05, 2025 too much vitamin B-6 can as well -- including from foods such as nuts -- as recently reported in two case reports

2.5 mg per injection 25 units Frequency Daily (5 on / 2 off) Weekly Total ~12.5 mg Cycle Length 4 6 weeks ~12.5 mg/wk 5 mg per injection 15 units Frequency Daily (5 on / 2 off) Weekly Total ~25 mg Cycle Length 6 8 weeks ~25 mg/wk 5 10 mg per injection 15 30 units Frequency Daily (5 on / 2 off) Weekly Total 25 50 mg Cycle Length 6 8 weeks 25 50 mg/wk Weekly Schedule All protocols follow a 5-on / 2-off injection pattern

Loading vs maintenance dosing protocols Loading phase dosing (Weeks 1-4): Why loading exists: Saturates tissue quickly Builds therapeutic levels fast Front-loads healing response Essential for good results Standard loading: 5mg twice weekly (10mg/week total) Days: Monday and Thursday (or Tuesday/Friday) 3-4 days between injections 4 weeks = 40mg total needed Aggressive loading (serious injuries): 7.5-10mg twice weekly (15-20mg/week) Used by athletes with major injuries Expensive but faster results 4 weeks = 60-80mg total Conservative loading (budget/prevention): 2.5mg twice weekly (5mg/week) Slower tissue saturation Takes longer to see results 4 weeks = 20mg total Maintenance phase dosing (Weeks 5+): Standard maintenance: 2-5mg once weekly Most use 2.5mg weekly Sustains therapeutic levels Continue 4-8 weeks after loading Why maintenance matters: Loading alone insufficient for deep healing Maintenance consolidates gains Prevents reinjury Keeps inflammation down Duration of maintenance: Minimum: 4 weeks Standard: 8 weeks Extended: 12+ weeks for chronic issues Total protocol examples: Standard 12-week protocol: Weeks 1-4: 5mg twice weekly = 40mg Weeks 5-12: 2.5mg once weekly = 20mg Total needed: 60mg (12 vials of 5mg) Cost: $540-$720 Aggressive 8-week protocol: Weeks 1-4: 7.5mg twice weekly = 60mg Weeks 5-8: 5mg once weekly = 20mg Total needed: 80mg (16 vials) Cost: $720-$960 FREE TOOLS FAQ What's the difference between TB-500 loading phase and maintenance phase