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The activity of the GSH-Px enzyme was reduced (about 25%) in both the liver and kidney of GK rats (Figure 2C)

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doi: 10.1152/physiol.00024.2006 133 WatermanR

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Research protocols typically employ intermittent dosing strategies (once weekly or 3-day cycles) designed to prevent excessive apoptosis while enabling effective senescent cell elimination, with doses ranging from 5-10 mg/kg body weight in animal studies