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Researchers should establish baseline data for each compound individually before assessing combinatorial effects, and all protocols should follow applicable institutional research guidelines

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TLR4 expression is increased in patients with GERD, triggering an inflammatory response involved in the further development of GERD.TLR4 expression in normal squamous epithelial samples is mainly confined to the basal layer of the squamous epithelium, which routinely may not come into contact with PAMPs expressed by the esophageal microbiota, and reflux increases TLR4 expression (49)

Course Description The required reading for this course was developed by an international, multidisciplinary panel that consisted of physicians, clinical researchers, and dietitians

doi: 10.3390/ijms25073784 115 XueQYanDChenXLiXKangRKlionskyDJet al