In addition, these organoids will provide a powerful tool to allow the investigation of cellular interactions, i.e., the mesoderm and endoderm, and how they contribute to inducing or co-developing these lineages
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Hepatocytes represent the majority of liver mass, while non-parenchymal cells include KCs, hepatic stellate cells (HSCs), liver sinusoidal endothelial cells, and infiltrating immune cells such as lymphocytes and neutrophils
Trends Endocrinol Metab (2013) 24:46980
NR4A1 knockout mice show enhanced resistance to ischemia-reperfusion injury, suggesting that the Nr4a1-Mff axis is a potential target for resistance to ischemia-reperfusion injury and ferroptosis in cardiomyocytes 47
