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The absence of gradual dose escalation likely amplified the drugs inhibitory effects on gastric motility, precipitating severe nausea, vomiting, and subsequent acute kidney injury due to dehydration

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These studies reveal that antioxidants serve two functions that are to boost the therapeutic impact and reduce side effects related to chemotherapy

The dysfunction of cellular metabolism further leads to various adverse effects

Dose and exposure in the models are often high or non-physiologic

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