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Theyre metabolically healthy enough to tolerate gradual caloric reduction, they dont have severe kidney disease (since semaglutide is renally cleared), and they have the support or resources to maintain adequate protein intake and physical activity during treatment

Im taking my chances

The study included 17,604 people who were at least 45 years old and had a body mass index greater than or equal to 27

That said, even at this low level, changes begin almost immediately for many researchers