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Semaglutide, the active ingredient in well known injectables like Ozempic and Wegovy, works by mimicking GLP-1, a hormone that helps regulate blood sugar, curb cravings, and promote steady weight loss
Patients losing significant amounts of weight over relatively short periods might potentially notice changes in temperature perception
Secondly, it acts on the brains reward system, reducing cravings and the desire to eat high-calorie foods
Some providers make exceptions for patients who were on maximum semaglutide, but this is not standard practice
Discontinuation typically leads to significant weight regain within 12 months, which is an important factor in long-term planning