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Metformin has been the cornerstone of type 2 diabetes management for decades

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Novo Nordisk moved to secure market leadership by commercially launching oral Wegovy earlier this year, while Eli Lilly is developing the small-molecule GLP-1 receptor agonist orforglipron with the goal of obtaining approval from the U.S

In fact, more than 15% of patients taking the standard 0.5 mg dose reported Ozempic nausea, over 7% reported Ozempic stomach pain, and 8.5% reported Ozempic diarrhea

It slows down gastric emptying, which means food stays in the stomach longer

Although not approved specifically for PCOS, GLP-1 RA use in women with PCOS has been associated with improved blood glucose control and weight loss, as well as improvements in menstrual regularity and a decrease in ovarian cysts ( 4 , 6 8 )