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The gutlung axis in asthma: microbiota-driven mechanisms and therapeutic perspectives

When to Contact Your Healthcare Provider About Diarrhea Mild diarrhea lasting 2-4 weeks during the titration phase is expected and typically does not require medication changes

Visible weight loss usually becomes noticeable between four and six weeks as dosing gradually increases

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Appetite changes often occur quite rapidly

However, other mechanisms, including the involvement of focal adhesion kinase (FAK), cannot be ruled out, given the rapid FAK activation by androgens in skeletal muscle cells [76]