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Characteristic symptoms of vitamin C deficiency include: swollen and bleeding gums fatigue poor wound healing joint pain loose teeth colored spots on the skin In some cases, signs of scurvy can occur within a month of consuming less than 10 milligrams (mg) per day of vitamin C

What is measured in these rats and mice (and occasionally in small groups of human volunteers) is often not a hard endpoint like muscle strength or weight loss, but surrogate biomarkers: molecules in the blood that have an indirect link to a hard endpoint