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Safety, tolerability and efficacy of up-titration of guideline-directed medical therapies for acute heart failure (STRONG-HF): a multinational, open-label, randomised, trial

Bachiller S, Hidalgo I, Garcia MG, Boza-Serrano A, Paulus A, Denis Q, et al

Given that these positions are primarily located in the hydrophobic environment of the lipid bilayer, the mutation range for these amino acids was restricted to 11 non-polar amino acids: ACFGILMPVWY

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Results showed that in both GSH dose groups, there was a reduction in oxidative stress, as indicated by decreases in the ratio of oxidized to reduced glutathione in whole blood after six months