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In multiple rodent models of chronic stress (a shared risk factor for major psychiatric illnesses), administration of LAC leads to a rapid and persistent antidepressant-like response by increasing histone acetylation and expression of key genes, including mGlu2 receptors and the downstream brain-derived neurotrophic factor BDNF [27, 30, 34,35,36,37]

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Mechanism of Action How Dihexa activates the HGF/c-Met pathway to promote synaptogenesis, dendritic spine formation, and long-term potentiation

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Further reading [edit] "Role of mitochondrial phospholipid hydroperoxide glutathione peroxidase (PHGPx) as an antiapoptotic factor"

Metallo CM, Gameiro PA, Bell EL, Mattaini KR, Yang J, Hiller K, et al