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The fourth arch derived palatoglossus and pharyngeal constrictors have similar innervation

Cysteine residues in Keap1 act as sensors for electrophiles and oxidants, and their oxidation leads to the release and subsequent translocation of Nrf2 into the nucleus where it can bind to the ARE4 sequence in the promoter region of genes involved in antioxidant defense (Moinova and Mulcahy 1999)

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These data support the rationale that tumors with elevated GST expression are more sensitive to the cytotoxic effects of TLK286

It does not usually require medical treatment