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Moreover, large scale population genetic studies indicated that loss of function mutations in APOC3 and APOA5 gene conferred decreased and increased risk of coronary artery disease (CAD), respectively

10.1016/j.jaut.2018.05.008 369 RobertsF

Because these conditions prevent adequate oral uptake, intramuscular injection bypasses the digestive system entirely and delivers B12 directly into muscle tissue for reliable absorption

It occurs when the body either becomes resistant to Insulins effects or doesnt produce enough Insulin to maintain normal glucose levels

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The findings are attention-grabbing not only because of the size of the dataset, but because they suggest these agents may have effects that extend beyond glycemic control and weight loss