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Reports suggested that around 20% of patients may suffer from acquired resistance despite they responded to anastrozole or to fluvestrant suggesting a role for ER in growth regulation even in many tamoxifen-resistant cases [44, 45]

Epitalon attenuated this effect, especially when the treatment was continued throughout the experiment (Group 2)

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This small compositional difference is the sole reason the two solutions behave so differently after the vial is opened the benzyl alcohol acts as a built-in defense against bacterial contamination whenever the stopper is pierced