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Studies on fibroblast cultures and tissue models have demonstrated its involvement in the modulation of the synthesis of collagen, fibronectin and glycosaminoglycans

Factors include patient preference, tolerance, administration convenience, and healthcare provider recommendations

SSRIs and other antidepressants increase BDNF over time, so combining them with exogenous BDNF modulators could theoretically produce additive or unpredictable effects

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