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However, under defined pathophysiological stresses, including inflammatory cues, metal overload, cysteine deprivation, or drug exposure, GSH oxidation and thiol chemistry may become coupled to metal redox cycling and mitochondrial damage amplification, thereby increasing susceptibility to forms of regulated cell death such as ferroptosis and cuproptosis

For GHK, the apo-peptide is the free tripeptide without coordinated copper

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Closed-loop DBS [364] as well as closed-loop optogenetic [365] methods could be very effective at elucidating cellular biomarkers in disease

Therefore, stable gastric pentadecapeptide BPC 157 is effective in wound healing (Seiwerth et al., 1997

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