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Mechanism-focused studies may include receptor-pathway assays, biomarker panels, gene-expression analysis, protein-expression studies, cell-viability controls, migration assays, metabolic marker analysis, or stability testing

While direct reproductive toxicity has been extensively documented, the mechanisms underlying heritable reproductive dysfunction represent an emerging frontier requiring intensive investigation ( Figure 3 )

Johansson F, Carlsson HA, Rasmussen A, Yeo CH, Hesslow G