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KLK5 and KLK7 ablation fully rescues lethality of netherton syndrome-like phenotype

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10.1038/s41467-023-42702-8 Nat Commun

An RCT in 36 patients with type 2 diabetes found that NAC (1,200 mg/day for 4 weeks) combined with a standard diabetes diet significantly reduced fasting glucose, HbA1c, and markers of oxidative stress compared to diet alone (Shahidi et al., J Diabetes Metab Disord, 2020) [56]

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Healthy donor T cells were added at E:T ratio of 3:1, along with varying concentrations of IL1RAPCD3 or IL1RAPCD3null complexes (0.97 to 62.5pM, 2-fold serial dilutions)