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Environ Sci Technol 47:66466655

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155 A randomized controlled trial conducted in China, where folic acid fortification of foods is voluntary, included 100 healthy adult participants with high homocysteine levels

It was effectively applied either immediately (prophylactically) after paracetamol challenge or (therapeutically) administered after a 3 h period had elapsed (note, the maximum depletion of hepatic glutathione occurred 3 h after acute paracetamol dosing (37))