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Hum Mol Genet 23 , 37163732, doi:10.1093/hmg/ddu080 (2014)

Together, these changes significantly lower the analogs affinity for IGF-binding proteins the regulatory proteins that normally limit how much circulating IGF-1 reaches cellular receptors

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TIMP-2 is a tissue inhibitor for MMP-2, another ECM protein

Effect of homocysteine-lowering B vitamin treatment on angiographic progression of coronary artery disease: a Western Norway B Vitamin Intervention Trial (WENBIT) substudy