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Purpose-built for physicians GLP-1 receptor agonists linked to lower mortality, respiratory failure in PAH Key takeaways: A link was found between GLP-1 receptor agonist use in PAH and significant decreases in mortality, respiratory failure, atrial fibrillation and ED visits

Li W, Yang G, Gan W (2017) REM sleep selectively prunes and maintains new synapses in development and learning

Metabolic adaptation reduces basal metabolic rate and non-exercise activity thermogenesis when calorie intake decreases, lowering total energy expenditure

Sun, C., Dong, S., Chen, W., Li, J., Luo, E., & Ji, J

Doses typically escalate gradually over weeks or months to help minimize any side effects

Research Evidence Comparison# CagriSema Research# The REDEFINE Phase 3 program provides robust evidence: REDEFINE 1 (3,417 participants, 20.4% weight loss at 68 weeks) and REDEFINE 2 (1,200 T2D participants, 13.7% weight loss)