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Accounting for these variables in both clinical and preclinical studies may improve risk stratification, biomarker discovery, and the development of ECM-targeted therapeutic strategies

Unfortunately, no interventions have been discovered to either slow the progress of Alzheimer's, and clinical trials have not succeeded in identifying disease-modifying strategies

Morissette R, Chen W, Perritt AF, et al

10.1038/s41586-021-03539-7 57 MijnhoutG

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PLoS ONE 9(11):e112207 Qin Q et al (2012) Astragalus membranaceus inhibits inflammation via phospho-P38 mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-B pathways in advanced glycation end product-stimulated macrophages