FraC pore formation, beyond protein-protein interaction, occurs thanks to lipids that do not act only in protein membrane recruitment but also participate in the assembly as a structural element of the pore, where each protein molecule is associated with three molecules of lipids [12,93]
It enhances neuronal survival, promotes angiogenesis and synaptic plasticity, and modulates key neurotransmitter systems, including dopaminergic, serotonergic, and GABAergic pathways
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J Leukoc Biol
Loss of TGH/Ces3 in mice decreases blood lipids, improves glucose tolerance, and increases energy expenditure