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Gradual titration is incorporated into trial protocols to improve gastrointestinal tolerability, as nausea and vomiting are most common during early treatment phases or rapid dose escalation [2]

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It has been suggested that in obese patients, these adipokines act peripherally, causing lipid accumulation, lipotoxicity, endoplasmic reticulum stress, mitochondrial dysfunction, and ultimately, cell apoptosis [111,112,113]

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People with metabolic issues have been shown to be deficient in Akkermansia, which can be associated with healthy weight management