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SURMOUNT-5 was a 72-week, open-label, Phase 3b randomised trial of 751 adults with obesity but without diabetes, comparing maximum-tolerated tirzepatide (10 or 15 mg) against maximum-tolerated semaglutide (1.7 or 2.4 mg)

By and large, views on the use and impact of weight-loss drugs are similar across most major demographic groups

The practical implication is that researchers should not assume any vial contains exactly what the label states

Pt 1, Jan

To the notion of lowering the recommended daily dose, the agency expected a "possible industry challenge." To the proposal to decrease the amount of acetaminophen per pill, the report anticipated "possible industry resistance to costs related to reformulation" and to "possible loss of revenue from elimination of 500 mg products." In June 2009, the agency gathered nearly 40 experts in a Maryland Marriott to weigh in on its recommendations

The microdose program uses sub-therapeutic doses primarily aimed at reducing food noise and cravings without the stronger appetite suppression of full doses