Both CT-388 and tirzepatide are dual GLP-1R/GIPR agonists, but they differ in peptide scaffold, fatty acid modification, half-life, and receptor signaling bias
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The analysis also linked GLP-1RA use with lower risks of lower extremity amputation, revascularization, gangrene, major adverse cardiovascular events, and all-cause mortality
Two researchers independently performed a preliminary screening of the titles and abstracts of all retrieved documents, and then read the full text of the documents screened in the first round to conduct a second screening based on the inclusion criteria, while recording the reasons for rejection
Method: ELISA Tests: 96 Incubation Time / Conditions: 1 h, 1 h (37C), 30 min (RT) Standard Range: 1.25 - 80 pmol/l Sensitivity analytical: 0.1 pmol/l Final Sample Volume: 100 l Sample Type: plasma (EDTA) Sample Pretreatment : - Isotope / Substrate / Mode: TMB 450 nm kBq: - Internal Controls: Regulatory Status: RUO
