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Acknowledgements Financial support is acknowledged from: the Ministero dell'Istruzione, dell'Universit e della Ricerca (Progetti di Rilevante Interesse Nazionale PRIN 2017), the Universit degli Studi di Salerno (FARB 2017), the SPRING cluster (REBIOCHEM research project CTN01_00063_49393), the Regione Campania for the FT-ICR mass spectrometer facility (POR CAMPANIA FESR 2007/2013 O.O.2.1, CUP B46D14002660009), the Farma-BioNet (CUP B25C13000230007) and the Centro di Tecnologie Integrate per la Salute for the 600 MHz NMR facility (CITIS, project PONa3_00138)

doi: 10.3892/or.2022.8428 136 VirayHMcDermottDFEinsteinDJ

Starting Doses Conservative protocols begin at 0.2-0.25 mg daily, allowing assessment of individual response before increasing dose

Double-blind trials confirm brighter, even tone in 8 weeks

Bending forward opens the spinal canal slightly and takes pressure off the nerves