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It works best when used with lifestyle modifications such as exercise and ha ealthy diet

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The paradox of Prader-Willi syndrome: a genetic model of starvation

They have the added advantages of weight loss, lower blood pressure and lower risk of hypoglycaemia

This guide breaks down the pharmacology, the mechanistic contrast, the head-to-head trial evidence (including the 2025 SURMOUNT-5 results), what enthusiast and research communities online are saying, and the practical realities of sourcing both compounds in Canada

It also promotes hepatic fat oxidation, meaning the liver breaks down stored fat more aggressively