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In rapidly reproducing tissues (such as the targeted tumour cells, but also hematopoietic cells and mucosal epithelium) unrepaired DSB and subsequent rounds of aberrant mitosis culminate in a morphotype of mitotic catastrophe and cell death [21]

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Deaminating the pyrimidine ring forms 5-amino-6-ribosylamino-2,4(1H,3H)-pyrimidinedione 5-phosphate