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In addition, stabilization of gutbrain signaling and substrate utilization may reduce metabolic stress during sustained energy deficit, thereby supporting a physiological environment more permissive to lean tissue retention

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Behavior Illustrative animal behavior on days and weeks after retrobulbar application of L-NAME when mounted on an elevated surface was that rats maintained the initial position of firmly standing on to the surface with posterior legs, almost frozen, with limited movements only (Figure 8, Figure 9)

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J Clin Endocrinol Metab (1964) 24:107682