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Peptide drug treatment Mice were treated via subcutaneous (s.c.) injection at the indicated doses with either long-acting acyl-GIP (100 nmol kg 1 s.c.), LIRA (100 nmol kg 1 s.c.) or an acylated peptide GIPR antagonist ([N-Ac,L14,R18,E21]hGIP(531)-K11(E-C16)) (1500 nmol kg 1 s.c.)

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This timeline reports what the published trials and community sources describe across the first week, the two-to-four-week window, and the five-to-eight-week mark, then covers the factors that move the curve and what an absent response usually means

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