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RIPK1 undergoes phosphorylation instead of ubiquitination, triggering the activation of RIPK3, which subsequently phosphorylates the mixed lineage kinase domain-like pseudokinase (MLKL)

Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients

Activation of UQCRC2-dependent mitophagy by tetramethylpyrazine inhibits MLKL-mediated hepatocyte necroptosis in alcoholic liver disease

This prompts caspase-1-mediated GSDMD cleavage, generating membrane pores and inducing pyroptosis in endothelial cells (Yu et al., 2024)