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For compounds with exactly 2 values (1,417), the closest to the mean method cannot be applied because mean is always at the middle of the two values

Treatment of NCI-H716 or STC-1 cells with the Ca 2+ ionophore ionomycin or with phorbol myristate acetate (PMA) increases cytosolic Ca 2+ levels and stimulates GLP-1 secretion in a dose-dependent manner [251,253]

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There have been reports of particularly severe acute pancreatitis, including necrotising and fatal pancreatitis, however, they are uncommon