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Fu W, Ge M, Li J

showed that in 24 patients undergoing knee or hip replacement surgeries, the incidence rates of PND at discharge and 3 months post-discharge were 75 and 45%, respectively (Koch et al., 2007)

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RNR is the rate-limiting enzyme of de novo nucleotide synthesis that reduces ribonucleotides to deoxyribonucleotides in a glutathione-dependent manner

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